Hot melt extrusion (HME) is a technique used to create solid dispersions of active pharmaceutical ingredients (APIs) like ketone ester, which is a liquid at room temperature. This process is particularly beneficial for poorly soluble drugs, as it can enhance their bioavailability by converting them into an amorphous form within a polymer matrix.

Material Preparation:

Using SiO (e.g., MCM-41) to improve Ketone ester loading capacity.

Ketone ester is mixed with a suitable polymer (e.g., Kollidon of BASF) and other excipients. The polymer acts as a carrier to form a solid matrix.

The mixture is typically pre-blended to ensure uniform distribution of the API and excipients.

Extrusion:

The blended mixture is fed into an extruder, where it is subjected to controlled heat and mechanical shear. The temperature is set above the glass transition temperature of the polymer but below the degradation point of the API.

Inside the extruder, the mixture is melted and mixed thoroughly, creating a homogeneous molten mass where the ketone ester is dispersed within the polymer matrix.

The molten mass is then forced through a die to form extrudates (strands or films).

Cooling and Solidification:

The extrudates are cooled, typically on a conveyor belt, to solidify the molten mass into a solid dispersion.

Once solidified, the extrudates are cut or milled into granules or pellets.

#Ketone #BHB #BetaHydroxybutyrate #Ketogenesis

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